作者： Yan-Lei · Ma/Ma YL;Yan-Ping · Liu/Liu YP;Chao · Zhang/Zhang C;Wan-Hui · Zhao/Zhao WH;Shi · Shi/Shi S;Dan-Nv · He/He DN;Pan · Zhang/Zhang P;Xiao-Hong · Liu/Liu XH;Ting-Ting · Han/Han TT;Yan-Hui · Fu/Fu YH （Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158, PR China. Electronic address: fuyanhui80@126.com.）

出处： Bioorganic chemistry 2018

关键词： Antiproliferative activities;Carbazole alkaloids;Clausehainanines A-E;Clausena hainanensis

摘要： Five new carbazole alkaloids, clausehainanines A-E (1-5), together with seven known analogues (6-12) were isolated from the stems and leaves of C. hai ...

作者： Yan-Ping · Liu/Liu YP;Jin-Ying · Tang/Tang JY;Yan · Hua/Hua Y;Liang · Lai/Lai L;Xiu-Lan · Luo/Luo XL;Zhi-Jie · Zhang/Zhang ZJ;Wen-Qing · Yin/Yin WQ;Guang-Ying · Chen/Chen GY;Yan-Hui · Fu/Fu YH （Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China. State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources of Ministry of Science and Technology, Guangxi Normal University, Guilin 541004, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China. State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources of Ministry of Science and Technology, Guangxi Normal University, Guilin 541004, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources of Ministry of Science and Technology, Guangxi Normal University, Guilin 541004, PR China College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China. Electronic address: fuyanhui80@163.com.）

出处： Bioorganic chemistry 2018

关键词： Artabotrys hongkongensis;Artahongkongenes A–F;Cytotoxicities;Polyoxygenated seco-cyclohexenes

摘要： Six new polyoxygenated seco-cyclohexenes, artahongkongenes A-F (1-6), together with six known analogues (7-12) were isolated from the stems and leaves ...

作者： A G E · Day/Day AGE;W R · Francis/Francis WR;K · Fu/Fu K;I L · Pieper/Pieper IL;O · Guy/Guy O;Z · Xia/Xia Z （Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK. Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK. Department of Orthopaedic Surgery, The First Affiliated Hospital of Hainan Medical College, Hainan, China. Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK. College of Engineering, Swansea University, Swansea SA2 8PP, UK. Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.）

出处： Stem cells international 2018

摘要： Coralline hydroxyapatite/calcium carbonate (CHACC) is a biodegradable and osteoconductive bone graft material with promising clinical performance. CHA ...

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作者： Qing-Shou Tan^1,2,3;Qiong-Tao Xie¹;Le-Man Kuang^2,3CA （1 College of Physics and Electronic Engineering, Hainan Normal University, Haikou, 571158, China; 2 Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education, Hunan Normal University, Changsha, 410081, China; 3 Department of Physics, Hunan Normal University, Changsha, 410081, China）

出处： Scientific Reports 2018

摘要： We consider the effects of dipole-dipole interactions on a nonlinear interferometer with spin-1 Bose-Einstein condensates. Compared with the tradition ...

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作者： Shanshan Wang^1,2;Mingyue Zhu³;Qiaoyun Wang³;Yuli Hou⁴;Lei Li⁵;Honglei Weng⁶;Yan Zhao⁴;Dexi Chen^1,2;Huiguo Ding⁵CA;Junli Guo³CA;Mengsen Li³CA （1 Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China; 2 Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China; 3 Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, China; 4 Clinical Laboratory Center, Beijing Youan Hospital, Capital Medical University, Beijing, China; 5 Department of Gastrointestinal and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China; 6 Molecular Hepatology, University of Heidelberg, University Medical Center Mannheim, 68167, Mannheim, Germany）

出处： Cell Death & Disease 2018

摘要： Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions ...

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作者： Rui Bi^1,2CA;Wen Zhang^1,3;Deng-Feng Zhang^1,2;Min Xu^1,4;Yu Fan^1,2;Qiu-Xiang Hu¹;Hong-Yan Jiang⁵;Liwen Tan⁶;Tao Li⁷;Yiru Fang⁸;Chen Zhang⁸;Yong-Gang Yao^1,4,9,10CA （1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; 2 Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China; 3 Department of Biochemistry and Molecular Biology and Key Laboratory of Molecular Biology, School of Basic Medicine and Life Sciences, Hainan Medical College, Haikou, 571199, China; 4 Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650204, China; 5 Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China; 6 Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, 410011, China; 7 The Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, 610064, China; 8 Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; 9 Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China; 10 KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan, 650223, China）

出处： Neuropsychopharmacology 2018

摘要： Alzheimer’s disease (AD) is the most common cause of dementia. Mitochondrial dysfunction has been widely reported in AD due to its important role in c ...

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作者： Sumin Zhao^1,2;Jiale Xiang³;Chunna Fan^1,2;Asan^1,2;Xuan Shang⁴;Xinhua Zhang⁵;Yan Chen⁶;Baosheng Zhu⁷;Wangwei Cai⁸;Shaoke Chen⁹;Ren Cai¹⁰;Xiaoling Guo¹¹;Chonglin Zhang¹²;Yuqiu Zhou¹³;Shuodan Huang¹⁴;Yanhui Liu¹⁵;Biyan Chen¹⁶;Shanhuo Yan¹⁷;Yajun Chen¹⁸;Hongmei Ding¹⁹;Fengyu Guo^1,2;Yaoshen Wang^1,2;Wenwei Zhong^1,2;Yaping Zhu^1,2;Yaling Wang^1,2;Chao Chen^1,2;Yun Li²⁰;Hui Huang³;Mao Mao³;Ye Yin³;Jian Wang^21,22;Huanming Yang^21,22;Xiangmin Xu⁴;Jun Sun^1,2CA;Zhiyu Peng^3,23CA （1 Tianjin Medical Laboratory, BGI-Tianjin, BGI-Shenzhen, 300308, Tianjin, China; 2 Binhai Genomics Institute, BGI-Tianjin, BGI-Shenzhen, 300308, Tianjin, China; 3 BGI Genomics, BGI-Shenzhen, 518083, Shenzhen, China; 4 Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, Guangdong, China; 5 Department of Hematology, 303rd Hospital of the People’s Liberation Army, Nanning, Guangxi, China; 6 The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China; 7 Nation Health and Family Planning Commission Key Laboratory For Preconception and Health Birth in Western China, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, China; 8 Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan, China; 9 Department of Genetic and Metabolic Laboratory, Guangxi Zhuang Autonomous Region Women and Children Health Care Hospital, Nanning, Guangxi, China; 10 Department of Medical Genetics, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China; 11 Maternity and Child Health Care Hospital of Foshan City, Foshan, Guangdong, China; 12 Guilin Women and Children Health Care Hospital, Guilin, Guangxi, China; 13 Department of Clinical Laboratory, Zhuhai Municipal Maternal and Child Healthcare Hospital, Zhuhai Institute of Medical Genetics, Zhuhai, Guangdong, China; 14 Maternal and Child Health Hospital in Meizhou, Meizhou, Guangdong, China; 15 Department of Prenatal Diagnosis Center, Dong Guan Maternal and Child Health Hospital, Dongguan, Guangdong, China; 16 Baise Women and Children Care Hospital, Baise, Guangxi, China; 17 Genetic Laboratory, Qinzhou Maternal and Child Health Hospital, Qingzhou, Guangxi, China; 18 Women and Children’s Health Hospital of Shaoguan, Shaoguan, Guangdong, China; 19 Department of Gynecology and Obstetrics, The People’s Hospital of Yunfu City, Yunfu, Guangdong, China; 20 BGI Clinical Laboratories-Shenzhen, BGI-Shenzhen, 518083, Shenzhen, China; 21 James D. Watson Institute of Genome Sciences, 310058, Hangzhou, China; 22 BGI-Shenzhen, 518083, Shenzhen, China; 23 BGI-Guangzhou Medical Laboratory, BGI-Shenzhen, 510006, Guangzhou, China）

出处： European Journal of Human Genetics 2018

摘要： Expanded carrier screening (ECS) has been demonstrated to increase the detection rate of carriers compared with traditional tests. The aim of this stu ...

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作者： Xuping Feng^1,2;Jing Zhou²;Jingyi Li³;Xueyan Hou⁴;Longhao Li^1,5;Yongmin Chen⁶;Shuyue Fu²;Li Zhou²;Changlong Li⁷;Yunlong Lei¹CA （1 Department of Biochemistry and Molecular Biology, and Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, P.R. China; 2 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China; 3 School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610083, P.R. China; 4 School of pharmacy, Xinxiang Medical University, Xinxiang, 453003, P. R. China; 5 Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China; 6 Department of Neurology, The Affiliated Hospital of Hainan Medical College, Hainan, 570102, P.R. China; 7 West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, P.R. China）

出处： Cell Death & Disease 2018

摘要： Cervical cancer is one of the most aggressive human cancers with poor prognosis due to constant chemoresistance and repeated relapse. Tubeimoside I (T ...

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作者： 芦燕 （三亚学院体育学院）

出处： 第二十八届全国高校田径科研论文报告会 2018

关键词： 意识形态理论；高校体育；文化建设

摘要： 高校学生作为国家未来的中坚力量,是打造意识形态的重要阵地。高校体育文化是意识形态载体的重要组成部分,通过物质、制度、精神、行为和价值等文化形态,营造意识形态氛围,实现对大学生意识形态教育。本文从意识形态理论视角出发,为加强高校体育文化建设,切实加强高校意识形态教育,为社会主义建设培养和输送优秀人才奠 ...

作者： Feng, Tiantian ¹ ;Wu, Jinyi ¹ ;Chai, Ke ¹ ;Yang, Pengpeng ¹  （¹  Key Laboratory of Advanced Materials of Tropical Island Resources (Hainan University), Ministry of Education, Material and Chemical Engineering Collage, Hainan University, Haikou 570228, China ）

出处： Bioelectrochemistry 2018

摘要： One of the most important research areas in the marine industry is to investigate new and effective anti-biofouling technologies. In this study, high ...